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Article

Computational screening of pathogenic missense nsSNPs in heme oxygenase 1 (HMOX1) gene and their structural and functional consequences.

Journal of biomolecular structure & dynamics - 1 Jul 2024

Yadav Arvind Kumar, Murthy T P Krishna, Divyashri Gangaraju, Prasad N Durga, Prakash Sriraksha, Vaishnavi V Vijaya, Shukla Rohit, Singh Tiratha Raj

Abstract excerpt

Heme Oxygenase 1 (HMOX1) is a cytoprotective enzyme, exhibiting the highest activity in the spleen, catalyzing the heme ring breakdown into products of biological significance- biliverdin, CO, and Fe2+. In vascular cells, HMOX1 possesses strong anti-apoptotic, antioxidant, anti-proliferative, anti-inflammatory, and immunomodulatory actions. The majority of these activities are crucial for the prevention of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Molecular Dynamics Simulation

Share to Mutation, Missense

Share to Polymorphism, Single Nucleotide

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Source

Identifiers

PMID: 37434323
DOI: 10.1080/07391102.2023.2231553

Genes

HMOX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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