Molecular Plasticity Results in Oncofetal Reprogramming and Therapeutic Vulnerabilities in Juvenile Myelomonocytic Leukemia.

doi:10.1158/2643-3230.BCD-25-0246

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Molecular Plasticity Results in Oncofetal Reprogramming and Therapeutic Vulnerabilities in Juvenile Myelomonocytic Leukemia.

Blood cancer discovery - 4 Mar 2026

Hartmann Mark, Schönung Maximilian, Rajak Jovana, Maurer Valentin, Hai Ling, Bauer Katharina, Hakobyan Mariam, Stäble Sina, Langstein Jens, Jardine Laura, Roelz Roland, Bohler Sheila, Khabirova Eleonora, Maag Abdul-Habib, Vonficht Dominik, Lebrecht Dirk, Bernt Kathrin M, Tan Kai, Chen Changya, Alikarami Fatemeh, Meyer Julia, Wang Jun, Boch Tobias, Flore Viktoria, Lutsik Pavlo, Milsom Michael D, Raffel Simon, Buske Christian, Haas Simon, Haniffa Muzlifah, Mallm Jan-Philipp, Behjati Sam, Bonder Marc-Jan, Fröhling Stefan, Stieglitz Elliot, Niemeyer Charlotte M, Hey Joschka, Flotho Christian, Plass Christoph, Erlacher Miriam, Schlesner Matthias, Lipka Daniel B

Abstract excerpt

Persistent fetal gene expression in childhood neoplasms is usually explained by a maturation block originating in the prenatal phase. In contrast, reactivation of fetal genes in adult malignancies is considered a consequence of oncofetal reprogramming (OFR) and is associated with aggressive disease. By reconstructing epigenetic ontogeny in juvenile myelomonocytic leukemia (JMML), we identified a postnatal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 41348944
DOI: 10.1158/2643-3230.BCD-25-0246

Genes

CD52
PTPN11

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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