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Article

Mutation signatures of pediatric acute myeloid leukemia and normal blood progenitors associated with differential patient outcomes.

Blood cancer discovery - 1 Sept 2021

Brandsma Arianne M, Bertrums Eline J M, van Roosmalen Markus J, Hofman Damon A, Oka Rurika, Verheul Mark, Manders Freek, Ubels Joske, Belderbos Mirjam E, van Boxtel Ruben

Abstract excerpt

Acquisition of oncogenic mutations with age is believed to be rate limiting for carcinogenesis. However, the incidence of leukemia in children is higher than in young adults. Here we compare somatic mutations across pediatric acute myeloid leukemia (pAML) patient-matched leukemic blasts and hematopoietic stem and progenitor cells (HSPCs), as well as HSPCs from age-matched healthy donors. HSPCs in the leukemic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34642666
DOI: 10.1158/2643-3230.BCD-21-0010
PMCID: PMC7611805

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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