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Article

iGWAS: Integrative Genome-Wide Association Studies of Genetic and Genomic Data for Disease Susceptibility Using Mediation Analysis.

Genetic epidemiology - 1 Jul 2015

Huang Yen-Tsung, Liang Liming, Moffatt Miriam F, Cookson William O C M, Lin Xihong

Abstract excerpt

Genome-wide association studies (GWAS) have been a standard practice in identifying single nucleotide polymorphisms (SNPs) for disease susceptibility. We propose a new approach, termed integrative GWAS (iGWAS) that exploits the information of gene expressions to investigate the mechanisms of the association of SNPs with a disease phenotype, and to incorporate the family-based design for genetic association...

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Identifiers

PMID: 25997986
DOI: 10.1002/gepi.21905
PMCID: PMC4544880

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MANEA
MRPL53
NDFIP1
PTCH1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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