Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Astrocyte MCT1 Expression Does Not Contribute to the Axonal Degenerative Phenotype Observed With Ubiquitous MCT1 Depletion.

Glia - 1 Feb 2026

Philips Thomas, Thompson Emily G, Spead Olivia, Vijayakumar Balaji G, Kent Erica R, Miller Sean J, Nwokeleme Treasure, Vidensky Svetlana, Farah Mohamed Hassan, Rothstein Jeffrey D

Abstract excerpt

We recently reported that the loss of oligodendrocyte metabolic support through the lactate and pyruvate transporter Monocarboxylate Transporter 1 (MCT1) is well tolerated into adulthood. Only with advanced aging did we observe axonal degeneration and hypomyelination due to the loss of MCT1 from oligodendroglia lineage cells. MCT1 is also expressed by other glial subtypes, such as astrocytes and endothelial cells...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging
Share to Astrocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Transgenic

Share to Monocarboxylic Acid Transporters

Share to Nerve Degeneration

Share to Oligodendroglia

Share to Symporters

Source

Open in PubMed Open full text

Identifiers

PMID: 41331335
DOI: 10.1002/glia.70113
PMCID: PMC12673003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Astrocyte MCT1 Expression Does Not Contribute to the Axonal Degenerative Phenotype Observed With Ubiquitous MCT1 Depletion.PMID 41331335Read ↗

MCT1 Deletion in Oligodendrocyte Lineage Cells Causes Late-Onset Hypomyelination and Axonal DegenerationSemantic proximity Read ↗

Loss of the astrocyte glutamate transporter GLT1 modifies disease in SOD1(G93A) mice.Semantic proximity Read ↗

MCT1-dependent energetic failure and neuroinflammation underlie optic nerve degeneration in Wolfram syndrome miceSemantic proximity Read ↗

An early endothelial cell-specific requirement for Glut1 is revealed in Glut1 deficiency syndrome model mice.Semantic proximity Read ↗

Myelin lipids as nervous system energy reservesSemantic proximity Read ↗

Astrocytic and endothelial GLUT1 restoration improves brain glucose homeostasis in GLUT1 deficiency syndromeSemantic proximity Read ↗

Metabolic reprogramming in astrocytes results in neuronal dysfunction in intellectual disability.Semantic proximity Read ↗

Astrocyte loss of mutant SOD1 delays ALS disease onset and progression in G85R transgenic mice.Semantic proximity Read ↗

ErbB inhibition impairs cognition via disrupting myelination and aerobic glycolysis in oligodendrocytesSemantic proximity Read ↗

Spatiotemporal Changes of Cerebral Monocarboxylate Transporter 8 Expression.Semantic proximity Read ↗

Deletion of astrocytic BMAL1 results in metabolic imbalance and shorter lifespan in mice.Semantic proximity Read ↗

Deletion of astrocyte connexins 43 and 30 leads to a dysmyelinating phenotype and hippocampal CA1 vacuolation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.