Article
An early endothelial cell-specific requirement for Glut1 is revealed in Glut1 deficiency syndrome model mice.
JCI insight - 8 Feb 2021
Tang Maoxue, Park Sarah H, Petri Sabrina, Yu Hang, Rueda Carlos B, Abel E Dale, Kim Carla Y, Hillman Elizabeth Mc, Li Fanghua, Lee Yeojin, Ding Lei, Jagadish Smitha, Frankel Wayne N, De Vivo Darryl C, Monani Umrao R
Abstract excerpt
Paucity of the glucose transporter-1 (Glut1) protein resulting from haploinsufficiency of the SLC2A1 gene arrests cerebral angiogenesis and disrupts brain function to cause Glut1 deficiency syndrome (Glut1 DS). Restoring Glut1 to Glut1 DS model mice prevents disease, but the precise cellular sites of action of the transporter, its temporal requirements, and the mechanisms linking scarcity of the protein to brain...
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