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Article

Deletion of astrocyte connexins 43 and 30 leads to a dysmyelinating phenotype and hippocampal CA1 vacuolation.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 17 Jun 2009

Lutz Sarah E, Zhao Yongmei, Gulinello Maria, Lee Sunhee C, Raine Cedric S, Brosnan Celia F

Abstract excerpt

Astrocytes are coupled via gap junctions (GJs) comprising connexin 43 (Cx43) (Gja1) and Cx30 (Gjb6), which facilitate intercellular exchange of ions. Astrocyte connexins also form heterotypic GJs with oligodendrocytic somata and lamellae. Loss of oligodendrocyte gap junctions results in oligodendrocyte and myelin pathology. However, whether loss of astrocyte GJs affects oligodendrocytes and myelin is not known....

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Source

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Identifiers

PMID: 19535586
DOI: 10.1523/JNEUROSCI.0341-09.2009
PMCID: PMC2737812

Genes

CA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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