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Article

Deletion of astrocytic BMAL1 results in metabolic imbalance and shorter lifespan in mice.

Glia - 1 Jun 2020

Barca-Mayo Olga, Boender Arjen J, Armirotti Andrea, De Pietri Tonelli Davide

Abstract excerpt

Disruption of the circadian cycle is strongly associated with metabolic imbalance and reduced longevity in humans. Also, rodent models of circadian arrhythmia, such as the constitutive knockout of the clock gene Bmal1, leads to metabolic disturbances and early death. Although astrocyte clock regulates molecular and behavioral circadian rhythms, its involvement in the regulation of energy balance and lifespan is...

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PMID: 31833591
DOI: 10.1002/glia.23764
PMCID: PMC7496695

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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