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Article

Spatiotemporal Changes of Cerebral Monocarboxylate Transporter 8 Expression.

Thyroid : official journal of the American Thyroid Association - 1 Sept 2020

Wilpert Nina-Maria, Krueger Martin, Opitz Robert, Sebinger David, Zschunke Sarah, Mages Bianca, Schulz Angela, Spranger Joachim, Wirth Eva K, Stachelscheid Harald, Mergenthaler Philipp, Vajkoczy Peter, Krude Heiko, Kühnen Peter, Bechmann Ingo, Biebermann Heike

Abstract excerpt

Background: Mutations of monocarboxylate transporter 8 (MCT8), a thyroid hormone (TH)-specific transmembrane transporter, cause a severe neurodevelopmental disorder, the Allan-Herndon-Dudley syndrome. In MCT8 deficiency, TH is not able to reach those areas of the brain where TH uptake depends on MCT8. Currently, therapeutic options for MCT8-deficient patients are missing, as TH treatment is not successful in...

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PMID: 32143555
DOI: 10.1089/thy.2019.0544

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TH

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