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Article

Loss of the astrocyte glutamate transporter GLT1 modifies disease in SOD1(G93A) mice.

Experimental neurology - 1 Sept 2006

Pardo Andrea C, Wong Victor, Benson Leah M, Dykes Margaret, Tanaka Kohichi, Rothstein Jeffrey D, Maragakis Nicholas J

Abstract excerpt

Recent studies have highlighted the role of astrocytes in the development of motor neuron disease in animal models. The astrocyte glutamate transporter GLT1 is responsible for a significant portion of glutamate transport from the synaptic cleft; regulating synaptic transmission and preventing glu...

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Source

Identifiers

PMID: 16753145
DOI: 10.1016/j.expneurol.2006.03.028

Genes

SOD1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16753145-2026-09-02.1. Manifest publication-graph-cohort-2026-09-02.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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