Article

ErbB inhibition impairs cognition via disrupting myelination and aerobic glycolysis in oligodendrocytes

2023-01-03

Abstract excerpt

White matter abnormalities are an emerging feature of schizophrenia, yet the underlying pathophysiological mechanisms are largely unknown. Disruption of ErbB signaling that is essential for peripheral myelination has been genetically associated with schizophrenia and white matter lesions in schizophrenic patients. However, the roles of ErbB signaling in oligodendrocytes remain elusive. Here, we used a pan-ErbB inh...

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Literature Corpus work: 99222e90-a438-5429-b036-a7f88ddf6b37
DOI: 10.1101/2023.01.03.522525

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