Article

Astrocytic and endothelial GLUT1 restoration improves brain glucose homeostasis in GLUT1 deficiency syndrome

2026-03-05

Abstract excerpt

Glucose transporter 1 deficiency syndrome (GLUT1-DS) is a severe neurometabolic disorder caused by impaired brain glucose transport. Because GLUT1 has been classically viewed as predominantly localized to blood–brain barrier endothelial cells, gene therapy strategies have largely focused on endothelial GLUT1 restoration. However, whether this endothelial-centered model fully explains disease pathogenesis and thera...

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Literature Corpus work: 1c010aeb-58f6-5a91-b866-49741bad87bc
DOI: 10.64898/2026.03.04.709430

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