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MUTACLASH: identifying functional small RNA target sites using crosslinking-induced mutations.

RNA (New York, N.Y.) - 16 Jan 2026

Wu Wei-Sheng, Lee Dong-En, Chung Chi-Jung, Lu Shang-Yi, Brown Jordan S, Zhang Donglei, Lee Heng-Chi

Abstract excerpt

Small RNAs play essential roles in gene regulation across diverse biological processes. Crosslinking, ligation, and sequencing of hybrids (CLASH) experiments have revealed that PIWI and Argonaute proteins can each bind a wide range of mRNA targets with distinct base-pairing rules, raising questions about the flexibility and functional relevance of these interactions. Given that crosslinking-induced mutations...

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PMID: 41330639
DOI: 10.1261/rna.080482.125
PMCID: PMC12810180

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