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Integration of strain and process optimization to increase autotrophic growth of engineered Komagataella phaffii.

New biotechnology - 25 Mar 2026

Baumschabl Michael, Lutz Lisa, Jecmenica Marina, Ata Özge, Mattanovich Diethard

Abstract excerpt

Synthetic autotrophs are a promising platform for sustainable bioproduction using CO2 as substrate. The methylotrophic yeast Komagataella phaffii has been engineered to use CO2 as the sole carbon source by integration of the Calvin-Benson-Bassham (CBB) cycle, based on its native methanol assimilating xylulose monophosphate (XuMP) cycle. Initial growth rates were low, but could be doubled by adaptive laboratory...

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Metabolic Engineering
Mutation
Saccharomycetales
Temperature

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 41317844
DOI: 10.1016/j.nbt.2025.11.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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