Adaptive laboratory evolution and reverse engineering enhances autotrophic growth in Pichia pastoris.

doi:10.1016/j.ymben.2021.11.007

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Article

Adaptive laboratory evolution and reverse engineering enhances autotrophic growth in Pichia pastoris.

Metabolic engineering - 1 Jan 2022

Gassler Thomas, Baumschabl Michael, Sallaberger Jakob, Egermeier Michael, Mattanovich Diethard

Abstract excerpt

Synthetic biology offers several routes for CO2 conversion into biomass or bio-chemicals, helping to avoid unsustainable use of organic feedstocks, which negatively contribute to climate change. The use of well-known industrial organisms, such as the methylotrophic yeast Pichia pastoris (Komagata...

Topics

Autotrophic Processes
Directed Molecular Evolution
Metabolic Engineering
Polymorphism, Single Nucleotide
Saccharomycetales

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