Article
Autotrophic adaptive laboratory evolution of the acetogen Clostridium autoethanogenum delivers the gas-fermenting strain LAbrini with superior growth, products, and robustness.
New biotechnology - 25 Nov 2024
Ingelman Henri, Heffernan James K, Harris Audrey, Brown Steven D, Shaikh Kurshedaktar Majibullah, Saqib Asfand Yar, Pinheiro Marina J, de Lima Lorena Azevedo, Martinez Karen Rodriguez, Gonzalez-Garcia Ricardo A, Hawkins Grant, Daleiden Jim, Tran Loan, Zeleznik Hunter, Jensen Rasmus O, Reynoso Vinicio, Schindel Heidi, Jänes Jürgen, Simpson Séan D, Köpke Michael, Marcellin Esteban, Valgepea Kaspar
Abstract excerpt
Microbes able to convert gaseous one-carbon (C1) waste feedstocks are increasingly important to transition to the sustainable production of renewable chemicals and fuels. Acetogens are interesting biocatalysts since gas fermentation using Clostridium autoethanogenum has been commercialised. However, most acetogen strains need complex nutrients, display slow growth, and are not robust for bioreactor fermentations....
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