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Article

Implications of evolutionary engineering for growth and recombinant protein production in methanol-based growth media in the yeast Pichia pastoris.

Microbial cell factories - 17 Mar 2017

Moser Josef W, Prielhofer Roland, Gerner Samuel M, Graf Alexandra B, Wilson Iain B H, Mattanovich Diethard, Dragosits Martin

Abstract excerpt

BACKGROUND: Pichia pastoris is a widely used eukaryotic expression host for recombinant protein production. Adaptive laboratory evolution (ALE) has been applied in a wide range of studies in order to improve strains for biotechnological purposes. In this context, the impact of long-term carbon source adaptation in P. pastoris has not been addressed so far. Thus, we performed a pilot experiment in order to analyze...

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Identifiers

PMID: 28302114
DOI: 10.1186/s12934-017-0661-5
PMCID: PMC5356285

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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