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Computational Analyses of Bifurcated Inter-Protein Interactions in Protein-Protein Assemblies Reveal Their Pivotal Role in Conferring Stability.

Proteins - 1 Apr 2026

Bheemireddy Sneha, Menon Revathy, Chavali Sreenivas, Sowdhamini Ramanathan, Srinivasan Narayanaswamy

Abstract excerpt

Majority of the proteome is constituted by oligomers and their function is governed by underlying protein-protein interactions. Interfacial residues, namely residues right at the interface of two protein chains, are known to confer stability and specificity in dimers. However, other interactions play a significant role in the formation and maintenance of oligomers in protein assemblies as well. Inter-protein...

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PMID: 41315005
DOI: 10.1002/prot.70090

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