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Article

Critical residue that promotes protein dimerization: a story of partially exposed Phe25 in 14-3-3σ.

Journal of chemical information and modeling - 24 Oct 2011

Liu Jing-Yuan, Li Zhaomin, Li Huian, Zhang Jian-Ting

Abstract excerpt

Many proteins exist and function as oligomers. While hydrophobic interactions have been recognized as the major driving force for oligomerization, detailed molecular mechanisms for the assembly are unknown. Here, we used 14-3-3σ as a model protein and investigated the role of hydrophobic residues at the dimeric interface using MD simulations and coimmunoprecipitations. We found that a half-exposed and half-buried...

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Identifiers

PMID: 21870863
DOI: 10.1021/ci200212y
PMCID: PMC3322420

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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