The Impact of Complement Factor H-Related Protein Gene Deletions on Kidney Transplantation.

Abstract excerpt

We recently reported that a homozygous deletion in the complement factor H-related (CFHR) locus predisposed kidney transplant patients to rejection. As donors carried intact genes, the susceptibility may have resulted from an alloimmune reaction to FHR proteins. However, we found no evidence for an anti-FH response. It is therefore possible that CFHR deletions as such affect the rejection risk. Here, we used MLPA...

Topics

• Humans
• Kidney Transplantation
• Complement C3b Inactivator Proteins
• Male
• Gene Deletion
• Female