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Article

High-depth sequencing characterization of viral dynamics across tissues in fatal COVID-19 reveals compartmentalized infection.

Nature communications - 2 Feb 2023

Normandin Erica, Rudy Melissa, Barkas Nikolaos, Schaffner Stephen F, Levine Zoe, Padera Robert F, Babadi Mehrtash, Mukerji Shibani S, Park Daniel J, MacInnis Bronwyn L, Siddle Katherine J, Sabeti Pardis C, Solomon Isaac H

Abstract excerpt

SARS-CoV-2 distribution and circulation dynamics are not well understood due to challenges in assessing genomic data from tissue samples. We develop experimental and computational workflows for high-depth viral sequencing and high-resolution genomic analyses from formalin-fixed, paraffin-embedded tissues and apply them to 120 specimens from six subjects with fatal COVID-19. To varying degrees, viral RNA is...

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COVID-19
COVID-19 Clinical Research Studies
Mutation
SARS-CoV-2
SARS-CoV-2 and COVID-19 Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

SARS-CoV-2 detection and testing

Spike Glycoprotein, Coronavirus

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Identifiers

PMID: 36732505
DOI: 10.1038/s41467-022-34256-y
PMCID: PMC9894515

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