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Article

SARS-CoV-2 strategically mimics proteolytic activation of human ENaC

26 May 2020

Abstract excerpt

Molecular mimicry is an evolutionary strategy adopted by viruses to exploit the host cellular machinery. We report that SARS-CoV-2 has evolved a unique S1/S2 cleavage site, absent in any previous coronavirus sequenced, resulting in the striking mimicry of an identical FURIN-cleavable peptide on the human epithelial sodium channel α-subunit (ENaC-α). Genetic alteration of ENaC-α causes aldosterone dysregulation in...

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PMID: 32452762
DOI: 10.7554/elife.58603

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