Genetic polymorphisms and expression of SARS-CoV-2 host entry genes associate with COVID-19 severity in an unvaccinated Moroccan cohort.

doi:10.1186/s12920-026-02367-w

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Article

Genetic polymorphisms and expression of SARS-CoV-2 host entry genes associate with COVID-19 severity in an unvaccinated Moroccan cohort.

BMC medical genomics - 18 Apr 2026

Aqillouch Safaa, Laazaazia Oumaima, Ouladlahsen Ahd, Noureddine Rachid, Baba Hanâ, Akarid Khadija, Benjelloun Soumaya, Pineau Pascal, Ezzikouri Sayeh

Abstract excerpt

BACKGROUND: Host molecular and genetic factors regulating SARS-CoV-2 entry are increasingly recognized as key determinants of infection susceptibility and disease severity. However, the combined impact of transcriptional and genetic variation in these pathways remains incompletely defined. This study aimed to identify clinically relevant biomarkers associated with COVID-19 outcomes by integrating gene expression...

Topics

Humans
COVID-19
Female
Polymorphism, Single Nucleotide
Furin
Serine Endopeptidases
SARS-CoV-2
Severity of Illness Index
Male
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Morocco

Adult

Genetic Predisposition to Disease

Virus Internalization

Angiotensin-Converting Enzyme 2

Case-Control Studies

Cohort Studies

Source

Open in PubMed Open full text

Identifiers

PMID: 41998646
DOI: 10.1186/s12920-026-02367-w
PMCID: PMC13220547

Genes

FURIN
TMPRSS2
ACE2
NRP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-41998646-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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