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A comprehensive germline variant and expression analyses of <i>ACE2</i> , <i>TMPRSS2</i> and SARS-CoV-2 activator <i>FURIN</i> genes from the Middle East: Combating SARS-CoV-2 with precision medicine

2020-05-16

Abstract excerpt

The severity of the new COVID-19 pandemic caused by the SARS-CoV-2 virus is strikingly variable in different global populations. SARS-CoV-2 uses ACE2 as a cell receptor, TMPRSS2 protease, and FURIN peptidase to invade human cells. Here, we investigated 1,378 whole-exome sequences of individuals from the Middle Eastern populations (Kuwait, Qatar, and Iran) to explore natural variations in the ACE2 , TMPRSS2, a...

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Literature Corpus work
0552573e-12ee-569f-b661-e54b140e9f0e
DOI
10.1101/2020.05.16.099176
Open publication

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A comprehensive germline variant and expression analyses of <i>ACE2</i> , <i>TMPRSS2</i> and SARS-CoV-2 activator <i>FURIN</i> genes from the Middle East: Combating SARS-CoV-2 with precision medicineDOI 10.1101/2020.05.16.099176
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