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Global Diversification and Distribution of Coronaviruses With Furin Cleavage Sites

7 Oct 2021

Abstract excerpt

Knowledge about coronaviruses (CoVs) with furin cleavage sites is extremely limited, although these sites mediate the hydrolysis of glycoproteins in plasma membranes required for MERS-CoV or SARS-CoV-2 to enter cells and infect humans. Thus, we have examined the global epidemiology and evolutionary history of SARS-CoV-2 and 248 other CoVs with 86 diversified furin cleavage sites that have been detected in 24...

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PMID: 34690939
DOI: 10.3389/fmicb.2021.649314

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