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Article

Clonal hematopoiesis may precede the diagnosis of aplastic anemia by several years.

Blood advances - 24 Feb 2026

Liu Qianwei, Fang Fang, Xue Huiwen, Wästerlid Tove, Smedby Karin Ekström, Liu Xinyuan

Abstract excerpt

ABSTRACT: Aplastic anemia (AA) is a bone marrow failure syndrome resulting from the immune destruction of hematopoietic stem cells. Clonal hematopoiesis (CH) is characterized by expansion of progenitor hematopoietic stem cells that harbor leukemogenic driver mutations. It has previously been shown that individuals with AA have a high prevalence of CH. However, the association between CH and AA remains unknown. We...

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Aged
Anemia, Aplastic
Clonal Hematopoiesis
Dioxygenases
DNA-Binding Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

DNA Methyltransferase 3A

Serine-Arginine Splicing Factors

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Open in PubMed Open full text

Identifiers

PMID: 41296017
DOI: 10.1182/bloodadvances.2024015776
PMCID: PMC12925114

Genes

ASXL1
DNMT3A
SRSF2
TET2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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