Article
Emergence of clonal hematopoiesis in the majority of patients with acquired aplastic anemia.
Cancer genetics - 1 Apr 2015
Babushok Daria V, Perdigones Nieves, Perin Juan C, Olson Timothy S, Ye Wenda, Roth Jacquelyn J, Lind Curt, Cattier Carine, Li Yimei, Hartung Helge, Paessler Michele E, Frank Dale M, Xie Hongbo M, Cross Shanna, Cockroft Joshua D, Podsakoff Gregory M, Monos Dimitrios, Biegel Jaclyn A, Mason Philip J, Bessler Monica
Abstract excerpt
Acquired aplastic anemia (aAA) is a nonmalignant disease caused by autoimmune destruction of early hematopoietic cells. Clonal hematopoiesis is a late complication, seen in 20-25% of older patients. We hypothesized that clonal hematopoiesis in aAA is a more general phenomenon, which can arise early in disease, even in younger patients. To evaluate clonal hematopoiesis in aAA, we used comparative whole exome...
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