Role of low-frequency integrase strand transfer inhibitor resistance mutations on virological outcomes in antiretroviral therapy-naïve individuals initiating second-generation integrase inhibitors.

doi:10.1016/j.jgar.2025.04.002

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Article

Role of low-frequency integrase strand transfer inhibitor resistance mutations on virological outcomes in antiretroviral therapy-naïve individuals initiating second-generation integrase inhibitors.

Journal of global antimicrobial resistance - 1 Jun 2025

Armenia Daniele, Marchegiani Greta, Spalletta Daniele, Carioti Luca, Tavelli Alessandro, Bellocchi Maria Concetta, Spagnuolo Vincenzo, Mazzotta Valentina, Quiros-Roldan Eugenia, Bono Valeria, Carrara Stefania, Lo Caputo Sergio, D'Arminio Monforte Antonella, Ceccherini-Silberstein Francesca, Rusconi Stefano, Santoro Maria Mercedes

Abstract excerpt

OBJECTIVES: This study investigated the role of low-frequency integrase strand transfer inhibitor (INSTI) resistance mutations, detectable by next-generation sequencing (NGS), at predicting virological rebound (VR) among people with HIV (PWH) starting second-generation INSTI-based first-line regimens. METHODS: This case-control study compared PWH (retrieved from the ICONA cohort; www.icona.org) who experienced VR...

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PMID: 40220787
DOI: 10.1016/j.jgar.2025.04.002

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