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Frequency of Major Transmitted Integrase Resistance in Poland Remains Low Despite Change in Subtype Variability.

Viruses - 11 Oct 2024

Mielczak Kaja, Serwin Karol, Urbańska Anna, Aksak-Wąs Bogusz, Karasińska-Cieślak Malwina, Mularska Elżbieta, Witor Adam, Jakubowski Paweł, Hlebowicz Maria, Bociąga-Jasik Monika, Jabłonowska Elżbieta, Szymczak Aleksandra, Szetela Bartosz, Łojewski Władysław, Parczewski Miłosz

Abstract excerpt

With the widespread use of integrase inhibitors and the expanding use of long-acting cabotegravir in both pre-exposure prophylaxis and antiretroviral treatment, molecular surveillance on the transmission of integrase resistance has regained clinical significance. This study aimed to determine the frequency of INSTI-transmitted drug resistance mutations (DRMs) among treatment-naïve individuals in Poland from 2016...

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Identifiers

PMID: 39459930
DOI: 10.3390/v16101597
PMCID: PMC11512334

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