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Article

Beware of resistance to 2nd-generation integrase inhibitors: A systematic meta-analysis of HIV-1 integrase inhibitors resistance and drug resistance mutations.

International journal of antimicrobial agents - 1 Sept 2024

Liu Shanshan, Yuan Defu, Zhou Ying, Wang Bei, Hu Haiyang

Abstract excerpt

OBJECTIVE: Assessing the prevalence of resistance and drug resistance mutations (DRMs) in HIV/AIDS patients towards integrase strand transfer inhibitors (INSTIs), particularly the 2nd-generation INSTIs, provides evidence for rational clinical drug use. METHODS: A systematic search was conducted on five databases to identify relevant literature reporting original data on INSTIs resistance. Meta-analyses,...

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Drug Resistance, Viral
HIV-1
HIV Infections
HIV Integrase
HIV Integrase Inhibitors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39096940
DOI: 10.1016/j.ijantimicag.2024.107294

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