Article

Reduced efficacy of HIV-1 integrase inhibitors in patients with drug resistance mutations in reverse transcriptase

2020-08-05

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>Little is known about the impact of pre-treatment drug resistance (PDR) to non-nucleoside reverse transcriptase inhibitors (NNRTIs) on the efficacy of second generation integrase inhibitors, now the standard of care drug class for HIV-1 treatment globally.<bold>Methods: </bold>We conducted next-generation sequencing on stored plasma specimens from the ADVANCE tr...

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Literature Corpus work: 80035e05-fbc3-5a33-b2c4-9a88fdf7ce92
DOI: 10.21203/rs.3.rs-45647/v1

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