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Article

TKC-MC: An Effective Strategy for Generating Heritable Heterozygous Mutations in Essential Genes in Rice.

Plant biotechnology journal - 1 Apr 2026

Xu Meilian, Yan Lang, Zhu Min, Zhan Zhitian, Chen Hong, Wang Dantong, Zheng Zhenping, Zhang Yujie, Xiong Lizhong, He Yubing

Abstract excerpt

The CRISPR/Cas9 gene-editing technology has been widely used in defining gene functions and crop improvement. However, some genes are essential for plant growth and development. Loss-of-function homozygous mutations in essential genes lead to plant death or sterility. Mutations in essential genes need to be maintained and propagated in heterozygous plants. CRISPR/Cas9 technology is highly efficient in generating...

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Identifiers

PMID: 41277604
DOI: 10.1111/pbi.70472
PMCID: PMC13140513

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