Article
Generation of inheritable and "transgene clean" targeted genome-modified rice in later generations using the CRISPR/Cas9 system.
Scientific reports - 19 Jun 2015
Xu Rong-Fang, Li Hao, Qin Rui-Ying, Li Juan, Qiu Chun-Hong, Yang Ya-Chun, Ma Hui, Li Li, Wei Peng-Cheng, Yang Jian-Bo
Abstract excerpt
The CRISPR/Cas9 system is becoming an important genome editing tool for crop breeding. Although it has been demonstrated that target mutations can be transmitted to the next generation, their inheritance pattern has not yet been fully elucidated. Here, we describe the CRISPR/Cas9-mediated genome editing of four different rice genes with the help of online target-design tools. High-frequency mutagenesis and a...
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