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Article

Concerns about the consequences of cancer predisposition and relationships with quality of life in young adults with Li-Fraumeni syndrome.

European journal of human genetics : EJHG - 1 Sept 2026

Forbes Shepherd Rowan, Rising Camella J, Moser Richard P, Huelsnitz Chloe O, Boyd Patrick, Wilsnack Catherine, Sleight Alix G, Klein William M P, Werner-Lin Allison, Hutson Sadie P, Han Paul K J, Khincha Payal P

Abstract excerpt

Li-Fraumeni syndrome (LFS) is an inherited condition associated with high multi-organ cancer risks from birth. Young adults (YAs; 18-39 years) with LFS experience psychosocial challenges that may negatively affect health-related quality of life (HRQOL). This study aimed to describe a specific psychosocial challenge, concerns about the consequences of LFS (CC-LFS), and investigate relationships among CC-LFS and...

Read the complete abstract on PubMed

Topics

Humans
Female
Quality of Life
Li-Fraumeni Syndrome
Adult

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Young Adult

Adolescent

Male

Genetic Predisposition to Disease

Mental Health

Source

Open in PubMed Open full text

Identifiers

PMID: 41276692
DOI: 10.1038/s41431-025-01984-w
PMCID: PMC13550586

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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