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Waiting and "weighted down": the challenge of anticipatory loss for individuals and families with Li-Fraumeni Syndrome.

Familial cancer - 1 Jul 2020

Werner-Lin Allison, Young Jennifer L, Wilsnack Catherine, Merrill Shana L, Groner Victoria, Greene Mark H, Khincha Payal P

Abstract excerpt

Li-Fraumeni Syndrome (LFS) is characterized by risk of multiple primary malignancies in diverse sites, pediatric onset, near complete penetrance by age 70 years, limited options for prevention, and substantial uncertainty regarding disease manifestation and prognosis. Forty-five families, including 117 individuals aged 13-81 years, enrolled in the US National Cancer Institute's Li-Fraumeni Syndrome Study...

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Identifiers

PMID: 32222840
DOI: 10.1007/s10689-020-00173-6
PMCID: PMC7440840

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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