Article
Molecular analysis of phenotypic heterogeneity in JAK2V617F-positive myeloproliferative neoplasms reveals a potential target for therapy.
British journal of haematology - 1 May 2023
Gu Wenjing, Tong Jingyuan, Fu Rongfeng, Sun Ting, Ju Mankai, Zhao Yanhong, Wang Di, Gao Jie, Liu Jinhua, Gao Yuchen, Li Huiyuan, Wang Wentian, Chi Ying, Yang Renchi, Chen Lu, Shi Lihong, Zhang Lei
Abstract excerpt
JAK2V617F is the most frequent mutation in BCR-ABL-negative myeloproliferative neoplasms (MPNs). It is an important but not the only determinant of MPN phenotype. We performed high-throughput sequencing on JAK2V617F+ essential thrombocythaemia (ET) and polycythaemia vera (PV) patient samples to unveil factors involved in phenotypic heterogeneity and to identify novel therapeutic targets for MPN. Two concurrent...
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