Article
Cell-autonomous megakaryopoiesis associated with polyclonal hematopoiesis in triple-negative essential thrombocythemia.
Scientific reports - 6 Sept 2021
Inano Tadaaki, Araki Marito, Morishita Soji, Imai Misa, Kihara Yoshihiko, Okuda Maho, Yang Yinjie, Ito Masafumi, Osaga Satoshi, Mano Hiroyuki, Edahiro Yoko, Ochiai Tomonori, Misawa Kyohei, Fukuda Yasutaka, Ando Jun, Komatsu Norio
Abstract excerpt
A subset of essential thrombocythemia (ET) cases are negative for disease-defining mutations on JAK2, MPL, and CALR and defined as triple negative (TN). The lack of recurrent mutations in TN-ET patients makes its pathogenesis ambiguous. Here, we screened 483 patients with suspected ET in a single institution, centrally reviewed bone marrow specimens, and identified 23 TN-ET patients. Analysis of clinical records...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.