Article

Different niches for mutant stem cells affect pathogenesis and therapy response in myeloproliferative neoplasms

2022-08-03

Abstract excerpt

<title>Abstract</title> <p>Aging facilitates the expansion of hematopoietic stem cells (HSCs) carrying clonal hematopoiesis (CH)-related somatic mutations and the development of myeloid malignancies, such as myeloproliferative neoplasms (MPNs). While cooperating mutations can cause transformation, it remains unclear whether distinct bone marrow (BM) HSC niches can influence the growth and therapy response of HSCs...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a98e619e-093b-57bc-99b1-01adbb6f8ba3
DOI: 10.21203/rs.3.rs-1875241/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Different niches for mutant stem cells affect pathogenesis and therapy response in myeloproliferative neoplasmsDOI 10.21203/rs.3.rs-1875241/v1Read

Different niches for stem cells carrying the same oncogenic driver affect pathogenesis and therapy response in myeloproliferative neoplasmsSemantic proximity Read

Insights into the Potential Mechanisms of JAK2V617F Somatic Mutation Contributing Distinct Phenotypes in Myeloproliferative NeoplasmsSemantic proximity Read

Sabotaged Integral HSC Heterogeneity Underlies Essential Thrombocythemia Development.Semantic proximity Read

The Hematopoietic Microenvironment in Myeloproliferative Neoplasms: The Interplay Between Nature (Stem Cells) and Nurture (the Niche).Semantic proximity Read

JAK2V617F mutant megakaryocytes contribute to hematopoietic aging in a murine model of myeloproliferative neoplasmSemantic proximity Read

Hematopoietic Stem Cell Heterogeneity Is Linked to the Initiation and Therapeutic Response of Myeloproliferative Neoplasms.Semantic proximity Read

The JAK2 mutation.Semantic proximity Read

How does JAK2V617F contribute to the pathogenesis of myeloproliferative neoplasms?Semantic proximity Read

Immunomodulatory role of megakaryocytes in the hematopoietic niche of myeloproliferative neoplasms.Semantic proximity Read

The mesenchymal niche in MDSSemantic proximity Read

From bone marrow failure syndromes to VEXAS: Disentangling clonal hematopoiesis, immune system, and molecular drivers.Semantic proximity Read

Clonal hematopoiesis and its impact on the aging osteo-hematopoietic niche.Semantic proximity Read