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Article

Impact of Hypoxia-Inducible Factor-1α Gene Polymorphisms on Renal Cell Carcinoma Susceptibility in a Chinese Han Population.

Lifestyle genomics - 1 Jan 2026

Liao Xinxin, Zhou Haibin, Huang Peng

Abstract excerpt

INTRODUCTION: Previous studies have reported the impact of the hypoxia inducible factor-1α (HIF1α) gene on risk of renal cell carcinoma (RCC). However, the results of these previous studies were inconsistent. Hence, this study aimed to verify the influence of single-nucleotide polymorphisms (SNPs) in the HIF1α gene and their interaction with environmental factors on RCC risk. METHODS: PCR-based restriction...

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Topics

Adult
Aged
Female
Humans
Male
Middle Aged
Carcinoma, Renal Cell

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Case-Control Studies

China

Genetic Predisposition to Disease

Genotype

Hypoxia-Inducible Factor 1, alpha Subunit

Kidney Neoplasms

Polymorphism, Restriction Fragment Length

Polymorphism, Single Nucleotide

Risk Factors

East Asian People

Source

Open in PubMed Open full text

Identifiers

PMID: 41263031
DOI: 10.1159/000548643
PMCID: PMC12721716

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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