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Article

Genetic polymorphisms in HIF1A are associated with prostate cancer risk in a Chinese population.

Asian journal of andrology - 1 Nov 2012

Li Pu, Cao Qiang, Shao Peng-Fei, Cai Hong-Zhou, Zhou Hai, Chen Jia-Wei, Qin Chao, Zhang Zheng-Dong, Ju Xiao-Bing, Yin Chang-Jun

Abstract excerpt

The hypoxia-inducible factor-1α (HIF-1α) plays an important role in regulating angiogenesis, which is essential for tumor growth and metastasis. Genetic variations of HIF1A (coding HIF-1α) have been shown to influence an individual's susceptibility to many human tumors; however, evidence on associations between HIF1A single-nucleotide polymorphisms (SNPs) and prostate cancer (PCa) risk is conflicting. We...

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PMID: 23042446
DOI: 10.1038/aja.2012.101
PMCID: PMC3720106

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