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Causal association between systemic lupus erythematosus and primary biliary cholangitis: A bidirectional Mendelian randomization study.

Medicine - 24 May 2024

Wang Ying, Zhou Zhe, Zhang Hai-Ping

Abstract excerpt

An association has been observed between systemic lupus erythematosus (SLE) and primary biliary cholangitis (PBC) in observational studies, however, the exact causal link remains unclear. We aim to evaluate the causal relationships between SLE and PBC through bidirectional Mendelian randomization (MR). Single-nucleotide polymorphisms (SNPs) were selected as instrumental variables from publicly accessible...

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Genetic Predisposition to Disease
Genome-Wide Association Study
Liver Cirrhosis, Biliary
Lupus Erythematosus, Systemic
Mendelian Randomization Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

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PMID: 38788005
DOI: 10.1097/MD.0000000000038282
PMCID: PMC11124658

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