Article
Multitrait genome-wide analyses identify new susceptibility loci and candidate drugs to primary sclerosing cholangitis.
Nature communications - 24 Feb 2023
Han Younghun, Byun Jinyoung, Zhu Catherine, Sun Ryan, Roh Julia Y, Cordell Heather J, Lee Hyun-Sung, Shaw Vikram R, Kang Sung Wook, Razjouyan Javad, Cooley Matthew A, Hassan Manal M, Siminovitch Katherine A, Folseraas Trine, Ellinghaus David, Bergquist Annika, Rushbrook Simon M, Franke Andre, Karlsen Tom H, Lazaridis Konstantinos N, McGlynn Katherine A, Roberts Lewis R, Amos Christopher I
Abstract excerpt
Primary sclerosing cholangitis (PSC) is a rare autoimmune bile duct disease that is strongly associated with immune-mediated disorders. In this study, we implemented multitrait joint analyses to genome-wide association summary statistics of PSC and numerous clinical and epidemiological traits to estimate the genetic contribution of each trait and genetic correlations between traits and to identify new lead PSC...
Topics
- Humans
- Genome-Wide Association Study
- Cholangitis, Sclerosing
- Phenotype
- Interferon Regulatory Factors
- Polymorphism, Single Nucleotide