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Article

Parkinson's-Linked LRRK2 and GBA1 Mutations Modulate the Peripheral Immune Response to Pseudomonas aeruginosa.

Movement disorders : official journal of the Movement Disorder Society - 1 Mar 2026

Mark Julian R, Staley Hannah A, Titus Ann M, Agin-Liebes Julian, Garrido Alicia, Hughes Laura, Dzamko Nicolas, Wallings Rebecca L, Tansey Malú Gámez

Abstract excerpt

BACKGROUND: Peripheral disease mechanisms such as immune dysregulation may contribute to Parkinson's disease (PD). To investigate interactions between common PD mutations and immune responses to environmental pathogens, we studied responses to Pseudomonas aeruginosa (P. aeruginosa) in peripheral blood mononuclear cells (PBMCs) from PD patients with leucine-rich repeat kinase 2 (LRRK2) mutations, GBA1 mutations,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41257354
DOI: 10.1002/mds.70123
PMCID: PMC13022586

Genes

GBA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 11 Sept 2026.

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Parkinson's-Linked LRRK2 and GBA1 Mutations Modulate the Peripheral Immune Response to Pseudomonas aeruginosa.PMID 41257354Read ↗

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