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Article

P2RX7, an adaptive immune response gene, is associated with Parkinson's disease risk and age at onset.

Journal of Parkinson's disease - 1 Nov 2024

Shani Shachar, Gana-Weisz Mali, Bar-Shira Anat, Thaler Avner, Gurevich Tanya, Mirelman Anat, Giladi Nir, Alcalay Roy N, Orr-Urtreger Avi, Goldstein Orly

Abstract excerpt

BACKGROUND: The adaptive immune response has a role in Parkinson's disease (PD). Patients with LRRK2 or GBA1 mutations often exhibit distinct clinical characteristics. OBJECTIVE: To evaluate the involvement of adaptive immune response genes in three PD groups: GBA1-PD, LRRK2-PD, and non-carrier (NC)-PD. METHODS: Differentially expressed genes (DEGs) associated with PD were identified using four datasets. Of them,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 39957192
DOI: 10.1177/1877718X241296015
PMCID: PMC13348328

Genes

P2RX7
GBA1
CD8B2
IL27RA
ZC3H12A

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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