Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

GBA1 and The Immune System: A Potential Role in Parkinson's Disease?

Journal of Parkinson's disease - 1 Jan 2022

Al-Azzawi Zaid A M, Arfaie Saman, Gan-Or Ziv

Abstract excerpt

It is clear that the immune system and inflammation have a role in Parkinson's disease (PD), including sporadic PD and some genetic forms such as LRRK2-associated PD. One of the most important genes associated with PD is GBA1, as variants in this gene are found in 5-20% of PD patients in different populations worldwide. Biallelic variants in GBA1 may cause Gaucher disease, a lysosomal storage disorder with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Glucosylceramidase
Share to Immune System
Share to Inflammation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Parkinson Disease

Source

Open in PubMed Open full text

Identifiers

PMID: 36057834
DOI: 10.3233/JPD-223423
PMCID: PMC9535551

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

GBA1 and The Immune System: A Potential Role in Parkinson's Disease?PMID 36057834Read ↗

Old disease—New reflections: Gaucher, immunity, and inflammationSemantic proximity Read ↗

The Role of Immune Dysfunction in Parkinson's Disease DevelopmentSemantic proximity Read ↗

The role of innate and adaptive immunity in Parkinson's disease.Semantic proximity Read ↗

Glucocerebrosidase deficiency leads to neuropathology via cellular immune activationSemantic proximity Read ↗

Convergence of signalling pathways in innate immune responses and genetic forms of Parkinson’s diseaseSemantic proximity Read ↗

Variants in PSMB9 and FGR differentially affect Parkinson's disease risk in GBA and LRRK2 mutation carriers.Semantic proximity Read ↗

Gba1 deletion causes immune hyperactivation and microbial dysbiosis through autophagic defectsSemantic proximity Read ↗

LRRK2 as a target for modulating immune system responses.Semantic proximity Read ↗

LRRK2 and the Immune System.Semantic proximity Read ↗

Autophagic dysfunction and gut microbiota dysbiosis cause chronic immune activation in a Drosophila model of Gaucher diseaseSemantic proximity Read ↗

Comparative Transcriptome Analysis in Monocyte-Derived Macrophages of Asymptomatic GBA Mutation Carriers and Patients with GBA-Associated Parkinson's Disease.Semantic proximity Read ↗

Down-regulation of B cell-related genes in peripheral blood leukocytes of Parkinson's disease patients with and without GBA mutations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.