Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Neural-genetic-environmental evidence for a disease factor in mental and physical health multimorbidity.

Nature communications - 18 Nov 2025

Chen Jin, Zhang Yuning, Liu Shu, Garcia-Argibay Miguel, Jia Tianye, Kang Jujiao, Li Wei, Solmi Marco, Sun Hongyi, Liu Wenqi, Chu Congying, Cortese Samuele, Wang Jiaojian

Abstract excerpt

Increasing evidence reveals the presence of multimorbidity across physical and mental disorders. A general disease factor (d factor) has been recently identified to capture the shared liability across these conditions, yet its biological basis remains poorly understood. Here, using data from the UK Biobank, we reveal the d factor's neural, genetic, and environmental underpinnings. We show that the d factor is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain
Share to Gene-Environment Interaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gray Matter

Share to Life Style

Share to Mendelian Randomization Analysis

Share to Mental Disorders

Share to United Kingdom

Share to White Matter

Source

Open in PubMed Open full text

Identifiers

PMID: 41253807
DOI: 10.1038/s41467-025-65055-w
PMCID: PMC12627566

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Neural-genetic-environmental evidence for a disease factor in mental and physical health multimorbidity.PMID 41253807Read ↗

Shared Genetic Liability across Systems of Psychiatric and Physical Illness.Semantic proximity Read ↗

A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank.Semantic proximity Read ↗

Brain-wide versus genome-wide vulnerability biomarkers for severe mental illnesses.Semantic proximity Read ↗

Multi-organ network of cardiometabolic disease-depression multimorbidity revealed by phenotypic and genetic analyses of MR images.Semantic proximity Read ↗

Multilayer Genomic Characterization of a Shared Genetic Factor Linking Depression-Related Liability and Reduced Physical Function.Semantic proximity Read ↗

Disease networks identify specific conditions and pleiotropy influencing multimorbidity in the general populationSemantic proximity Read ↗

Combining polygenic risk scores to understand genetic liability to physical-mental health multimorbidity in UK Biobank.Semantic proximity Read ↗

Atlas of the Human Brain Imaging-derived Phenotypes and Disease RiskSemantic proximity Read ↗

Combining polygenic risk scores to understand genetic liability to physical-mental health multimorbidity in UK BioBankSemantic proximity Read ↗

Exploring the genetic architecture of multimorbidity and its impact on long COVID riskSemantic proximity Read ↗

Index of multiple deprivation contributed to common psychiatric disorders: A systematic review and comprehensive analysis.Semantic proximity Read ↗

A multivariate genome-wide association study of psycho-cardiometabolic multimorbidity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.