Article
Multi-organ network of cardiometabolic disease-depression multimorbidity revealed by phenotypic and genetic analyses of MR images.
Nature communications - 7 Jan 2026
Wang Jingxuan, Liu Mianxin, Liu Feng, Yang Guangrui, Yuan Zhongshang, Huang Hao, Zhang Zixuan, Wang Lilong, Wu Ye, Fan Wenliang, Shi Shuxiao, Chen Meng, Jiang Xuanwei, Yan Qiaoling, Lan Jun, Liu Xiaoming, Rong Shuang, Feng Nannan, Zhong Victor W
Abstract excerpt
The development and progression of cardiometabolic diseases and depression multimorbidity involves pathophysiological processes across multiple organs. Using multi-organ imaging data from 31,246 UK Biobank participants, we investigate the multi-organ manifestations and their phenotypic connections and shared genetic architecture underlying the multimorbidity. Phenotypic analyses identify seven abdominal, 16...
Topics
Join the communities discussing this publication.