Article
Quaking, an RNA-binding protein, is a critical regulator of vascular smooth muscle cell phenotype.
Circulation research - 12 Oct 2013
van der Veer Eric P, de Bruin Ruben G, Kraaijeveld Adriaan O, de Vries Margreet R, Bot Ilze, Pera Tonio, Segers Filip M, Trompet Stella, van Gils Janine M, Roeten Marko K, Beckers Cora M, van Santbrink Peter J, Janssen Anique, van Solingen Coen, Swildens Jim, de Boer Hetty C, Peters Erna A, Bijkerk Roel, Rousch Mat, Doop Merijn, Kuiper Johan, Schalij Martin Jan, van der Wal Allard C, Richard Stéphane, van Berkel Theo J C, Pickering J Geoffrey, Hiemstra Pieter S, Goumans Marie Jose, Rabelink Ton J, de Vries Antoine A F, Quax Paul H A, Jukema J Wouter, Biessen Erik A L, van Zonneveld Anton Jan
Abstract excerpt
RATIONALE: RNA-binding proteins are critical post-transcriptional regulators of RNA and can influence pre-mRNA splicing, RNA localization, and stability. The RNA-binding protein Quaking (QKI) is essential for embryonic blood vessel development. However, the role of QKI in the adult vasculature, and in particular in vascular smooth muscle cells (VSMCs), is currently unknown. OBJECTIVE: We sought to determine the...
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