Article

TMEM106B modifies TDP-43 pathology in human ALS brain and cell-based models of TDP-43 proteinopathy

2021-05-08

Abstract excerpt

<h4>ABSTRACT</h4> The neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with TAR DNA-binding protein-43 (TDP-43) inclusions (FTLD-TDP) share the neuropathological hallmark of aggregates of TDP-43. However, factors governing the severity and regional distribution of TDP-43 pathology, which may account for the divergent clinical presentations of ALS and FTLD-TDP, a...

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Literature Corpus work: 69c7a7ea-e366-5d48-aec9-b9d1b61c3bbe
DOI: 10.1101/2021.05.07.442949

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