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Article

Association of Multiple-trait Polygenic Risk Score with Obesity and Cardiometabolic Diseases in Korean Population.

Genomics, proteomics & bioinformatics - 28 Oct 2025

Jo Jinyeon, Ha Nayoung, Ji Yunmi, Do Ahra, Seo Je Hyun, Oh Bumjo, Choi Sungkyoung, Choe Eun Kyung, Lee Woojoo, Son Jang Won, Won Sungho

Abstract excerpt

We conducted a comprehensive genetic investigation of obesity in a cohort of 93,673 Korean individuals, categorized by body mass index and waist circumference using Korean-specific and international criteria. To explore the genetic architecture of obesity and its related comorbidities, we performed genome-wide association studies and constructed polygenic risk scores (PRSs) using both conventional single-trait...

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Asian People
Body Mass Index
Cardiovascular Diseases
Diabetes Mellitus, Type 2
Genetic Risk Score

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Multifactorial Inheritance

Republic of Korea

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Identifiers

PMID: 41206923
DOI: 10.1093/gpbjnl/qzaf102
PMCID: PMC12975335

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